Science Based

[Modex - Pycnogenol® Powered]

98% of studies on Medline pertaining to French maritime pine bark extract have been performed based on Pycnogenol® These studies outline the effectiveness on the inflammatory system, oxidative stress and its capacity to generate the vasodilator molecule, Nitric Oxide (NO), leading to many benefits for those living an active lifestyle. 



Pycnogenol Sports Nitric Oxide Modex natural

Pycnogenol’s Unique Source

Pycnogenol French maritime pine bark extract is extracted from the bark of mono-species pine trees grown exclusively in Les Landes de Gascogne forest in southwest France. The forest is unspoiled and natural, with no pesticides, no herbicides. The premium quality of Pycnogenol components comes from the fact the bark is not subject to seasonal variations, unlike other plants, which makes it an ideal botanical source. The extraction process of Pycnogenol is patented, and complies with the highest quality standards, following Good Agricultural Practice (GAP). The manufacturing plant is Good Manufacturing Practices (GMP) compliant, and the production process does not include any toxic solvent.

Pycnogenol is sourced from Les Landes de Gascogne forest in southwest France and French forestry legislation provides that fallen trees are to be replaced every year.

How does Pycnogenol work?

Pycnogenol is a naturally programmed combination with constant proportions of procyanidins, bioflavonoids and organic acids. It is 20 times more potent than Vitamin C and 50 times more potent than Vitamin E which offer amazing properties as one of the most potent natural scavengers of free radicals.

It gets to work in our body in many different ways, mopping up aggressive radicals before they cause damage by oxidative stressacts as a natural anti-inflammatory and aids in the production of endothelial nitric oxide which increases blood flow, influencing exercise efficiency, muscle contractility, cellular energy respiration and glucose uptake (read further). 

Free radicals - why fight them? 

In every day life our body generates free radicals, especially in case of physical exercise & stress. These chemically unbalanced radicals damage cells by oxidizing them, in the same way as metal becomes rusty and destroyed. Hence, free radicals are dangerous and scientists believe the continuous exposure to free radicals can be harmful and effect our performance. As a super-antioxidant, Pycnogenol® is believed to counteract that danger in two ways:
- it stimulates our cells to double their antioxidative power and
- it catches free radicals in the blood stream.
That double defense makes Pycnogenol® unique.

Is Pycnogenol® safe?

Pycnogenol® is one of the most researched food supplements and has passed extensive safety tests. Toxicity test results demonstrate that Pycnogenol® is safe, even at high doses for long periods of time. To date, no serious adverse side effects are observed or reported in clinical trials. Mild side effects as gastro-intestinal discomfort, headache, nausea and dizziness were seldom reported. It is best to take Pycnogenol® with or after meals to avoid an a possible upset stomach. Pycnogenol® is certified kosher, halal and is "self-affirmed" GRAS  (Generally Recognized as Safe).

Modex® has a concentration purposely designed to mimic other bodily fluids like blood (same osmotic pressure). This optimises the rapid absorption of nutrients (in particular Pycnogenol) into the bloodstream. 

Papain enzymes plays a key role to clear your stomach at an optimal rate in order to maximise absorption. It allows our formula to move from the stomach to your small intestine in a fast controlled way, resisting nutrient degradation and being gentle on your system.

Pycnogenol’s Role as a Sports Nutrition Energy Enhancer

  1. Physical exercise increases our body’s need for oxygen. The blood flow characteristics play a key role for oxygen supply to muscle, return of carbon dioxide to the lungs and delivery of lactic acid to the liver. Only sufficient muscle oxygenation warrants aerobic energy generation and prevents anaerobic build-up of lactic acid. Research in General Physiology and Biophysics demonstrated Pycnogenol’s ability to improve blood flow characteristics, helping the body achieve peak muscle performance and integrity.
  2. Nitric oxide (NO), the most prominent vascular mediator, enhances blood flow and plays a key role for the vascular response to exercise. Pycnogenol has the capacity to support vascular requirements during exercise and accelerates production of endothelial nitric oxide. If the body experiences insufficient production of NO, the blood flow is impaired.

The Importance of Nitric Oxide for Muscle Recovery and Energy

  1. Nitric Oxide (NO) is the body’s main Vasodilator. Vasodilation is the physiological process in which the diameter of blood vessels is widened to increase blood flow. Nitric Oxide improves the flow of blood and the delivery of oxygen and nutrients to the muscles. Nitric Oxide is produced from arginine an amino acid obtained from many protein rich foods. Arginine is converted to nitric oxide by an enzyme called nitric oxide synthase. In our blood vessels, the enzyme is called endothelial nitric oxide synthase, abbreviated to eNOS.

  2. The enzyme eNOS is found in the body in limited amounts. Therefore, only so much nitric oxide can be generated at any one time because the enzyme is a limiting agent. When Modex supplement is consumed, the Pycnogenol acts on the endothelial cells in the blood vessels to switch on the synthesis of eNOS (Nishioka et al, 2007). As there is more eNOS then it is possible to produce more nitric oxide. Moreover, PBE activates eNOS- it makes the enzyme work faster so nitric oxide is generated more rapidly. This is very important for the active athlete

  3. Dilated blood vessels allow more efficient nutrient delivery to activate muscles and other tissues. More efficient blood supply will also allow higher levels of oxygen to be transported at a quicker rate to our tissues, including our active muscles. Dilated blood vessels also include our venous system which will allow the faster elimination of toxic waste product from the body. Nitric Oxide is important during exercise because it is able to boost the function of mitochondria in cells, including those in skeletal muscle cells. Mitochondria are the energy generating units in cells. The substrate that goes into mitochondria are simple sugars such as glucose and these are converted into the energy unit, ATP. Nitric Oxide boosts the speed at which glucose is converted to ATP and it facilitates the entry of glucose into the cell. The faster glucose can be taken up by cells, the faster it can be converted into ATP Energy.

Pycnogenol’s Role in Muscle Recovery, Pain and Cramp Reduction

Muscle cramping is a common problem for people of all ages, ranging from the fit to people who suffer from health problems. An increase in physical activity can lend itself to sore muscles and fatigue, which can take several days to subside.

  1. A study published in Angiology shows that supplementation with Pycnogenol improves blood flow to the muscles which speeds recovery after physical exercise. The study demonstrated that Pycnogenol significantly reduces muscular pain and cramps in athletes and healthy, normal individuals. Poor circulation in the muscle is known to cause cramps and the antioxidant improved the cramping in patients due to a stimulation of blood flow to their muscle tissue.
  2. According to one of the lead researchers of the study Dr. Peter Rohdewald, the findings indicate that Pycnogenol can play an important role in sports by improving blood flow to the muscles and hastening post exercise recovery. This is great news to the millions of athletes worldwide and extremely significant for all individuals interested in muscle cramp and pain relief with a natural approach.

As new research breakthroughs on Pycnogenol for sports nutrition continue to be discovered, the findings thus far seem to indicate that Pycnogenol plays an important role for sports nutrition.

Extract from Total Health Magazine

The link between Pycnogenol and sports endurance was first studied several years ago at California State University. Recreational athletes showed an increase of athlete endurance while supplementing with Pycnogenol as compared to endurance recorded from participants taking the placebo.

Effects of supplementation of Pycnogenol on fitness. 

In a recent study athletes results were monitored for a 2 mile run, Push up test, Sit up test across a 4 week training program as well as a triathlon.


The study monitored the results for a triathlon consisting of a 750m Swim, 20km Ride and 5km Run. They undertook this course 10 times across 30 days with one group supplementing 150mg Pycnogenol per day and the other not whilst both following the same nutritional and training program. 

The average time of the Pycnogenol subjects was improved by 10 minutes and 48 seconds (11.39%) and the average time of the controlled subjects was improved by only 4 minutes 36 seconds (5.12%)   


Female subjects supplementing Pycnogenol improved their times on average by 11% where as controlled subjects improved their times by 1% 

Male subjects supplementing Pycnogenol improved their times on average by 17.4% where as controlled subjects improved their times by 7.9%


Female subjects supplementing Pycnogenol improved their max reps by 22% (39 push ups) where as controlled subjects improved their max reps by 9% (31-34.1 push ups)

Male subjects supplementing Pycnogenol improved their max reps by 22% (56-69 push ups) where as controlled subjects improved their max reps by 9% (58-62 push ups)


Female subjects supplementing Pycnogenol improved their max reps by 9.4% (61-67 sit ups) where as controlled subjects improved 4.8% (61.2-64.2 sit ups) 

Male subjects supplementing Pycnogenol improved their max reps by 14.67% (63.2-73.2 sit ups) where as controlled subjects improved 6.3% (63.2-67.3 sit ups)


A significant decrease in cramps and running and post-running pain was seen in the Pycnogenol group; there were no significant differences in controls. There was an important, significant post-triathlon decrease of PFR (Plasma Free Radicals) one hour after the end of the triathlon with an average of -26.7, whereas PFR in controls increased. In Pycnogenol subjects there was a lower increase in oxidative stress with a faster recovery to almost normal levels (<330 for these subjects). These variations in PFR values were interpreted as a faster metabolic recovery in subjects using Pycnogenol. 


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